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Literature summary extracted from

  • Amory, J.K.; Wang, C.; Swerdloff, R.S.; Anawalt, B.D.; Matsumoto, A.M.; Bremner, W.J.; Walker, S.E.; Haberer, L.J.; Clark, R.V.
    The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men (2007), J. Clin. Endocrinol. Metab., 92, 1659-1665.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 dutasteride 0.5 mg/day, dual 5alpha-reductase inhibitor Homo sapiens
1.3.1.22 finasteride 5.0 mg/day, effective inhibitor of type 2 5alpha-reductase Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+ + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 5alpha-reductase type 1 the isoenzyme predominates in the reproductive tissues, genital skin, and epididymis Homo sapiens
1.3.1.22 5alpha-reductase type 2 the isoenzyme is predominantly found in the skin, liver, and testes Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Homo sapiens