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Literature summary extracted from

  • Hong, B.S.; Senisterra, G.; Rabeh, W.M.; Vedadi, M.; Leonardi, R.; Zhang, Y.M.; Rock, C.O.; Jackowski, S.; Park, H.W.
    Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder (2007), J. Biol. Chem., 282, 27984-27993.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.33 expression as a His-tagged fusion protein in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.33 sitting drop vapor diffusion method at 18°C, homodimeric structures of the catalytic core of PanK1alpha in complex with acetyl-CoA. Crystallographic mapping of missense mutations associated with pantothenate kinase-associated neurodegeneration disease Homo sapiens
2.7.1.33 sitting drop vapor diffusion method at 18°C, homodimeric structures of the catalytic core of PanK3 in complex with acetyl-CoA. Crystallographic mapping of missense mutations associated with pantothenate kinase-associated neurodegeneration disease Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.33 acetyl-CoA a feedback inhibitor; a feedback inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.33 ATP + pantothenate Homo sapiens pantothenate kinase catalyzes the first step in CoA biosynthesis ADP + 4'-phosphopantothenate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.33 Homo sapiens Q8TE04
-
-
2.7.1.33 Homo sapiens Q9H999
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.33
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.33 ATP + D-pantothenate
-
 Homo sapiens ADP + 4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + pantothenate pantothenate kinase catalyzes the first step in CoA biosynthesis Homo sapiens ADP + 4'-phosphopantothenate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.33 PanK1alpha
-
 Homo sapiens
2.7.1.33 PanK3
-
 Homo sapiens