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Literature summary extracted from

  • Hillebrand, M.; Verrier, S.E.; Ohlenbusch, A.; Schaefer, A.; Soeling, H.D.; Wouters, F.S.; Gaertner, J.
    Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3) (2007), J. Biol. Chem., 282, 26997-27005.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.6.2.4 medicine mutations in the gene encoding ALDP result in a devasting neurodegenerative disorder, X-linked adrenoleukodystrophy, X-ALD Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.4 into pECFP-N1 and pEYFP-N1 vectors for transfection of VERO cells Homo sapiens
7.6.2.4 into pECFP-N1, pEYFP-N1, or pECFP-C1 vectors for transfection of VERO cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
7.6.2.4 ALDP390 mutant, comprises the amino acids 1 to 390 Homo sapiens
7.6.2.4 ALDP550 mutant, comprises the amino acids 1 to 550 Homo sapiens
7.6.2.4 ALDP658 mutant, comprises the amino acids 1 to 658 Homo sapiens
7.6.2.4 ALDPDELTA551-657 mutant, residues 551-657 are deleted Homo sapiens
7.6.2.4 ALDPDELTANBF mutant, residues 391-657 are deleted Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.4 peroxisomal membrane
-
 Homo sapiens 5778
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.6.2.4 70000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.4 ATP + H2O + fatty acyl CoA/cis Homo sapiens
-
 ADP + phosphate + fatty acyl CoA/trans
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.4 ATP + H2O + fatty acyl CoA/cis
-
 Homo sapiens ADP + phosphate + fatty acyl CoA/trans
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.4 dimer ALDP can form homodimers as well as heterodimers with the peroxisomal membrane protein PMP70 Homo sapiens
7.6.2.4 dimer PMP70 can form homodimers as well as heterodimers with the adrenoleukodystrophy protein ALDP Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
7.6.2.4 ABCD1
-
 Homo sapiens
7.6.2.4 ABCD3
-
 Homo sapiens
7.6.2.4 adrenoleukodystrophy protein
-
 Homo sapiens
7.6.2.4 ALDP
-
 Homo sapiens
7.6.2.4 fatty-acyl-CoA-transporting ATPase
-
 Homo sapiens
7.6.2.4 peroxisomal ABC transporter
-
 Homo sapiens
7.6.2.4 PMP70
-
 Homo sapiens