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Literature summary extracted from

  • Perez-Victoria, F.J.; Sanchez-Canete, M.P.; Castanys, S.; Gamarro, F.
    Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites (2006), J. Biol. Chem., 281, 23766-23775.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.1 plasma membrane LdMT and LdRos3 Leishmania donovani 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.1 ATP + H2O + miltefosine/in Leishmania donovani LdMT and LdRos3 form part of the same translocation machinery that determines flippase activity and miltefosine sensitivity in Leishmania ADP + phosphate + miltefosine/out
-
 ?
7.6.2.1 ATP + H2O + phospholipid/in Leishmania donovani LdMT Is required but not sufficient for the inward-directed translocation activity of phospholipids and miltefosine across the plasma membrane, LdRos3 is additionally required ADP + phosphate + phospholipid/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.1 Leishmania donovani
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.1 ATP + H2O + miltefosine/in
-
 Leishmania donovani ADP + phosphate + miltefosine/out
-
 ?
7.6.2.1 ATP + H2O + miltefosine/in LdMT and LdRos3 form part of the same translocation machinery that determines flippase activity and miltefosine sensitivity in Leishmania Leishmania donovani ADP + phosphate + miltefosine/out
-
 ?
7.6.2.1 ATP + H2O + phospholipid/in
-
 Leishmania donovani ADP + phosphate + phospholipid/out
-
 ?
7.6.2.1 ATP + H2O + phospholipid/in LdMT Is required but not sufficient for the inward-directed translocation activity of phospholipids and miltefosine across the plasma membrane, LdRos3 is additionally required Leishmania donovani ADP + phosphate + phospholipid/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.1 flippase
-
 Leishmania donovani
7.6.2.1 LdMT
-
 Leishmania donovani
7.6.2.1 LdRos3 beta-subunit of LdMT Leishmania donovani
7.6.2.1 miltefosine transporter
-
 Leishmania donovani
7.6.2.1 More the enzyme belongs to the P-type ATPases, LdRos3 belongs to the CDC50/Lem3 family, proposed as likely beta-subunits for P4-ATPases Leishmania donovani