Literature summary extracted from

Bolger, G.B.; Peden, A.H.; Steele, M.R.; MacKenzie, C.; McEwan, D.G.; Wallace, D.A.; Huston, E.; Baillie, G.S.; Houslay, M.D.
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2 (2003), J. Biol. Chem., 278, 33351-33363.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.4.53	expression in COS7 cells	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.4.53	rolipram	-	Rattus norvegicus
3.1.4.53	XAP2	noncompetitive inhibition, aryl-hydrocarbon receptor-interacting protein XAP2 inhibits PDE4A5 activity by XAP2 does not require any intermediate proteins. XAP2 inhibits PDE4A5 and not other PDE4 isoforms	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.53	Rattus norvegicus	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
3.1.4.53	phosphoprotein	aryl-hydrocarbon receptor-interacting protein XAP2 attenuates the ability of cAMP-dependent protein kinase to phosphorylate PDE4A5	Rattus norvegicus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.53	adenosine 3',5'-cyclic phosphate + H2O	attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2	Rattus norvegicus	adenosine 5'-phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.4.53	PDE4A5	-	Rattus norvegicus

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3.1.4.53	0.000099	-	XAP2	-	Rattus norvegicus
3.1.4.53	0.074	-	rolipram	-	Rattus norvegicus

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Release 2023.1 (January 2023)