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Literature summary extracted from

  • Sanchez, P.; Torres, J.M.; Vilchez, P.; Del Moral, R.G.; Ortega, E.
    Effects of sulpiride on mRNA levels of steroid 5alpha-reductase isozymes in prostate of adult rats (2008), IUBMB Life, 60, 68-72.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.22 sulpiride 40 mg/kg doses induce mRNA expression of 5alphaR1 and 5alpha-R2 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus P24008 isozyme 5alpha-R1
-
1.3.1.22 Rattus norvegicus P31214 isozyme 5alpha-R2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 prostate gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+
-
 Rattus norvegicus 5alpha-dihydrotestosterone + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 5alpha-R1 isozyme Rattus norvegicus
1.3.1.22 5alpha-R2 isozyme Rattus norvegicus
1.3.1.22 steroid 5alpha-reductase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Rattus norvegicus