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Literature summary extracted from

  • Hirose, Y.; Tsutsui, T.W.; Ohno, M.; Barrett, J.C.; Tsutsui, T.
    Effects of a catechol-O-methyltransferase inhibitor on catechol estrogen-induced cellular transformation, chromosome aberrations and apoptosis in Syrian hamster embryo cells (2007), Int. J. Cancer, 120, 1627-1633.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.6 medicine COMT activity has an influence on cell transforming activity and its related genetic effects of catechol estrogens imply that an individual activity of COMT may be one of the etiological factors in endogenous estrogen-induced carcinogenesis Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Mesocricetus auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 embryo
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 2-hydroxyestrone + S-adenosyl-L-methionine the production of 2-methoxyestrone in cultures treated with 2-hydroxyestrone is approximately 2fold that of 4-methoxyestrone in cultures treated with 4-hydroxyestrone Mesocricetus auratus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 4-hydroxyestrone + S-adenosyl-L-methionine
-
 Mesocricetus auratus S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.6 COMT
-
 Mesocricetus auratus