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Literature summary extracted from

  • Kidd, S.P.; Jiang, D.; Jennings, M.P.; McEwan, A.G.
    Glutathione-dependent alcohol dehydrogenase AdhC is required for defense against nitrosative stress in Haemophilus influenzae (2007), Infect. Immun., 75, 4506-4513.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.284 gene adhC, encoded in the adhC-estD operon, expression of the adhC-estD operon is regulated by NmlRHI in strain Rd KW20, the Neisseria MerR-like regulator, overview. The NmlRHI-AdhC system in the genome sequences of nontypeable Haemophilus influenzae strains R2846, R2866, and 86-028NP shows variations, the adhC gene of strain 86-028NP is nonfunctional due to a premature stop codon, polymorphisms in the operator/promoter region of strain R2866 result in reduced enzyme activity, genotyping of clinical isolates, in silico promoter analysis, overview Haemophilus influenzae

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.284 additional information chromosomal inactivation of either adhC or nmlRHI resulted in sensitivity to S-nitrosoglutathione and decreased S-nitrosoglutathione reductase activity, the NmlRHI-AdhC system in the genome sequences of nontypeable Haemophilus influenzae strains R2846, R2866, and 86-028NP shows variations, the adhC gene of strain 86-028NP is nonfunctional due to a premature stop codon, polymorphisms in the operator/promoter region of strain R2866 result in reduced enzyme activity, genotyping of clinical isolates, overview Haemophilus influenzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.284 additional information Haemophilus influenzae genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview ?
-
 ?
1.1.1.284 additional information Haemophilus influenzae KW20 genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.284 Haemophilus influenzae A5HES9 strain Rd KW20, gene adhC
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1.1.1.284 Haemophilus influenzae KW20 A5HES9 strain Rd KW20, gene adhC
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.284 additional information genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview Haemophilus influenzae ?
-
 ?
1.1.1.284 additional information AdhC has NADH-dependent S-nitrosoglutathione reductase activity Haemophilus influenzae ?
-
 ?
1.1.1.284 additional information genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview Haemophilus influenzae KW20 ?
-
 ?
1.1.1.284 additional information AdhC has NADH-dependent S-nitrosoglutathione reductase activity Haemophilus influenzae KW20 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.284 AdhC
-
 Haemophilus influenzae
1.1.1.284 class III alcohol dehydrogenase
-
 Haemophilus influenzae
1.1.1.284 glutathione-dependent alcohol dehydrogenase
-
 Haemophilus influenzae
1.1.1.284 GSNO reductase
-
 Haemophilus influenzae
1.1.1.284 NADH-GSNO oxidoreductase
-
 Haemophilus influenzae
1.1.1.284 S-nitrosoglutathione reductase
-
 Haemophilus influenzae

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.284 NADH dependent on Haemophilus influenzae