Literature summary extracted from

Gupta, K.K.; Bharne, S.S.; Rathinasamy, K.; Naik, N.R.; Panda, D.
Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding (2006), FEBS J., 273, 5320-5332.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.6.5.6	curcumin	-	Capra hircus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.6.5.6	GTP + H2O	Capra hircus	-	GDP + phosphate	-	ir

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.6.5.6	Capra hircus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.6.5.6	goat brain microtubule protein is isolated by two cycles of polymerization and depolymerization, MAP-free tubulin is purified from the microtubule protein by phosphocellulose chromatography	Capra hircus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.6.5.6	brain	-	Capra hircus	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
3.6.5.6	5.6	-	in the presence of 50 microM curcumin	Capra hircus
3.6.5.6	7.1	-	-	Capra hircus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.6.5.6	GTP + H2O	-	Capra hircus	GDP + phosphate	-	ir

Subunits

EC Number	Subunits	Comment	Organism
3.6.5.6	heterodimer	alpha-beta dimer	Capra hircus

Synonyms

EC Number	Synonyms	Comment	Organism
3.6.5.6	tubulin GTPase	-	Capra hircus

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.6.5.6	37	-	GTPase assay	Capra hircus

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Release 2023.1 (January 2023)