Literature summary extracted from

Yu, Z.; Yang, Q.; Sun, J.; Zhen, J.
Dihydropyrimidine dehydrogenase activity correlates with fluorouracil sensitivity in breast cancer (2007), Exp. Oncol., 29, 192-196.

Application

EC Number	Application	Comment	Organism
1.3.1.1	medicine	DPD is a molecular marker for identifying tumor cells sensitivity in breast cancer patients receiving 5-fluorouracil-based chemotherapy	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.1.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.1.1	breast cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.1.1	5-fluorouracil + NADH + H+	-	Homo sapiens	5-fluoro-5,6-dihydrouracil + NAD+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.3.1.1	dihydropyrimidine dehydrogenase	-	Homo sapiens
1.3.1.1	DPD	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.3.1.1	NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)