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Literature summary extracted from

  • An, S.; Jang, Y.S.; Park, J.S.; Kwon, B.M.; Paik, Y.K.; Jeong, T.S.
    Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes (2008), Exp. Mol. Med., 40, 407-417.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 oleic acid anilide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 Hep-G2 cell
-
 Homo sapiens
-
2.3.1.26 THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT
-
 Homo sapiens
2.3.1.26 acyl-coenzyme A:cholesterol acyltransferase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.26 0.0152
-
 inhibited ACAT activity in THP-1 macrophages Homo sapiens oleic acid anilide