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Literature summary extracted from

  • Liu, J.; Cao, R.; Yi, W.; Ma, C.; Wan, Y.; Zhou, B.; Ma, L.; Song, H.
    A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds (2009), Eur. J. Med. Chem., 44, 1773-1778.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 1-(1-(4-methoxyphenyl)propan-2-ylidene)-thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-(2,5-dimethyl-1H-pyrrol-1-yl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-(3-methylbutylidene)thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-(3-oxocyclohexylidene)thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-(3-phenylallylidene)thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-(4-(4-hydroxyphenyl)butan-2-ylidene)-thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-(4-methylpent-3-en-2-ylidene) thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-(but-2-enylidene)thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-(butan-2-ylidene)thiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-(propan-2-ylidene)thiosemicarbazide most potent inhibitor Agaricus bisporus
1.14.18.1 1-cyclohexylidenethiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-cyclopentylidenethiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-ethylidenethiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 1-propylidenethiosemicarbazide
-
 Agaricus bisporus
1.14.18.1 4-methoxycinnamic acid
-
 Agaricus bisporus
1.14.18.1 arbutin
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.18.1 5360
-
-
 Agaricus bisporus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-dopa + 1/2 O2
-
 Agaricus bisporus L-dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.1 6.8
-
 assay at Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.000086
-
 most potent inhibitor Agaricus bisporus 1-(propan-2-ylidene)thiosemicarbazide
1.14.18.1 0.00017
-
-
 Agaricus bisporus 1-cyclopentylidenethiosemicarbazide
1.14.18.1 0.0002
-
-
 Agaricus bisporus 1-propylidenethiosemicarbazide
1.14.18.1 0.00023
-
-
 Agaricus bisporus 1-ethylidenethiosemicarbazide
1.14.18.1 0.00028
-
-
 Agaricus bisporus 1-(butan-2-ylidene)thiosemicarbazide
1.14.18.1 0.00042
-
-
 Agaricus bisporus 1-(1-(4-methoxyphenyl)propan-2-ylidene)-thiosemicarbazide
1.14.18.1 0.00054
-
-
 Agaricus bisporus 1-(4-(4-hydroxyphenyl)butan-2-ylidene)-thiosemicarbazide
1.14.18.1 0.00062
-
-
 Agaricus bisporus 1-(3-methylbutylidene)thiosemicarbazide
1.14.18.1 0.00085
-
-
 Agaricus bisporus 1-(2,5-dimethyl-1H-pyrrol-1-yl)thiourea
1.14.18.1 0.00095
-
-
 Agaricus bisporus 1-cyclohexylidenethiosemicarbazide
1.14.18.1 0.001
-
-
 Agaricus bisporus 1-(but-2-enylidene)thiosemicarbazide
1.14.18.1 0.0027
-
-
 Agaricus bisporus 1-(3-phenylallylidene)thiosemicarbazide
1.14.18.1 0.0115
-
-
 Agaricus bisporus 1-(4-methylpent-3-en-2-ylidene) thiosemicarbazide
1.14.18.1 0.0151
-
-
 Agaricus bisporus 1-(3-oxocyclohexylidene)thiosemicarbazide
1.14.18.1 0.41
-
-
 Agaricus bisporus 4-methoxycinnamic acid
1.14.18.1 10.4
-
-
 Agaricus bisporus arbutin