Literature summary extracted from

van Kuilenburg, A.B.; Klumpen, H.; Westermann, A.M.; Zoetekouw, L.; Van Lenthe, H.; Bakker, P.J.; Richel, D.J.; Guchelaar, H.
Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorin (2007), Eur. J. Cancer, 43, 459-465.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.3.1.1	leucovorin	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.1.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.1.1	buccal mucosa	-	Homo sapiens	-
1.3.1.1	peripheral blood mononuclear cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.1.1	5-fluorouracil + NADH + H+	-	Homo sapiens	5-fluoro-5,6-dihydrouracil + NAD+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.3.1.1	dihydropyrimidine dehydrogenase	-	Homo sapiens
1.3.1.1	DPD	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.3.1.1	NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)