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Literature summary extracted from

  • Cui, L.; Miao, J.; Furuya, T.; Fan, Q.; Li, X.; Rathod, P.K.; Su, X.Z.; Cui, L.
    Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development (2008), Eukaryot. Cell, 7, 1200-1210.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 anacardic acid reversibly and noncompetitively inhibits HAT activity with a 50% inhibitory concentration of 0.03 nM. The parasiticidal effect of anacardic acid is at least partially associated with its inhibition of PfGCN5 HAT, resulting in the disturbance of the transcription program in the parasites Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4
-
 Plasmodium falciparum CoA + acetylhistone H4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 HAT
-
 Plasmodium falciparum
2.3.1.48 histone acetyltransferase
-
 Plasmodium falciparum
2.3.1.48 PfGCN5 HAT
-
 Plasmodium falciparum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.48 0.026
-
 inhibition of recombinant PfGCN5 Plasmodium falciparum anacardic acid