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Literature summary extracted from

  • Gubitosi-Klug, R.A.; Talahalli, R.; Du, Y.; Nadler, J.L.; Kern, T.S.
    5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy (2008), Diabetes, 57, 1387-1393.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.34 additional information 5-LO-deficient mice show an inhibition of diabetes-induced acellular capillary formation in retina, and show reduced leukostasis and superoxide generation, diabetic enzyme-deficient mice show suppression of NF-kappaB expression, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 by leukotriene A4 hydrolase, which binds to its specific receptor ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus C57BL/6
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 by leukotriene A4 hydrolase, which binds to its specific receptor ?
1.13.11.34 arachidonic acid + O2 Mus musculus
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 arachidonic acid + O2 Mus musculus C57BL/6
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Mus musculus
-
 C57BL/6 mice
-
1.13.11.34 Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 pericyte
-
 Mus musculus
-
1.13.11.34 retina retinal blood vessels of wild-type and mutant mice, diabetic mice show increased expression of leukotriene B4 receptors Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus leukotriene A4 + H2O
-
 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 by leukotriene A4 hydrolase, which binds to its specific receptor ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus C57BL/6 leukotriene A4 + H2O
-
 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus C57BL/6 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 by leukotriene A4 hydrolase, which binds to its specific receptor ?
1.13.11.34 arachidonic acid + O2
-
 Mus musculus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 arachidonic acid + O2
-
 Mus musculus C57BL/6 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Mus musculus