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Literature summary extracted from

  • Lee, S.S.; Kim, W.Y.; Jang, Y.J.; Shin, J.G.
    Duplex pyrosequencing of the TPMT3C and TPMT6 alleles in Korean and Vietnamese populations (2008), Clin. Chim. Acta, 398, 82-85.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine individuals with decreased TPMT activity are at high risk of fatal adverse reactions if treated with conventional thiopurine doses Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.67 238G>C TPMT variant Homo sapiens
2.1.1.67 460G>A TPMT variant Homo sapiens
2.1.1.67 539A>T TPMT variant Homo sapiens
2.1.1.67 719A>G TPMT variant Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens ?
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens ?
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + azathioprine
-
 Homo sapiens ?
-
 ?