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Literature summary extracted from

  • Chen, J.; Gong, Y.; Liu, J.; Hua, W.; Zhang, L.; Sun, H.
    Synthesis and biological evaluation of novel pyrazolo[4,3-b]oleanane derivatives as inhibitors of glycogen phosphorylase (2008), Chem. Biodivers., 5, 1304-1312.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.1 1'-(methylsulfonyl)pyrazolo[4,3-b]olean-12-en-28-oic acid
-
 Oryctolagus cuniculus
2.4.1.1 1'-acetylpyrazolo[4,3-b]olean-12-en-28-oic acid
-
 Oryctolagus cuniculus
2.4.1.1 1'-propanoylpyrazolo[4,3-b]olean-12-en-28-oic acid
-
 Oryctolagus cuniculus
2.4.1.1 4-oxo-4-[(pyrazolo[4,3-b]olean-12-en-28-yl)oxy]butanoic acid
-
 Oryctolagus cuniculus
2.4.1.1 benzyl 1'-(2,4-dichlorobenzyl)pyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
2.4.1.1 benzyl 1'-(carboxymethyl)pyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
2.4.1.1 benzyl 1'-benzylpyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
2.4.1.1 benzyl 1'-methylpyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
2.4.1.1 benzyl 1'-[(ethoxycarbonyl)methyl]pyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
2.4.1.1 benzyl pyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
2.4.1.1 Caffeine
-
 Oryctolagus cuniculus
2.4.1.1 oleanolic acid
-
 Oryctolagus cuniculus
2.4.1.1 pyrazolo[4,3-b]olean-12-en-28-oic acid
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.1 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.1 muscle
-
 Oryctolagus cuniculus
-

Synonyms

EC Number Synonyms Comment Organism
2.4.1.1 glycogen phosphorylase
-
 Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.1 0.0099
-
 pH 7.2, 22°C Oryctolagus cuniculus pyrazolo[4,3-b]olean-12-en-28-oic acid
2.4.1.1 0.014
-
-
 Oryctolagus cuniculus oleanolic acid
2.4.1.1 0.0247
-
 pH 7.2, 22°C Oryctolagus cuniculus 4-oxo-4-[(pyrazolo[4,3-b]olean-12-en-28-yl)oxy]butanoic acid
2.4.1.1 0.0372
-
 pH 7.2, 22°C Oryctolagus cuniculus 1'-propanoylpyrazolo[4,3-b]olean-12-en-28-oic acid
2.4.1.1 0.0456
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl pyrazolo[4,3-b]olean-12-en-28-oate
2.4.1.1 0.0493
-
 pH 7.2, 22°C Oryctolagus cuniculus 1'-(methylsulfonyl)pyrazolo[4,3-b]olean-12-en-28-oic acid
2.4.1.1 0.0538
-
 pH 7.2, 22°C Oryctolagus cuniculus 1'-acetylpyrazolo[4,3-b]olean-12-en-28-oic acid
2.4.1.1 0.057
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-(carboxymethyl)pyrazolo[4,3-b]olean-12-en-28-oate
2.4.1.1 0.063
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-benzylpyrazolo[4,3-b]olean-12-en-28-oate
2.4.1.1 0.0999
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-methylpyrazolo[4,3-b]olean-12-en-28-oate
2.4.1.1 0.111
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-[(ethoxycarbonyl)methyl]pyrazolo[4,3-b]olean-12-en-28-oate
2.4.1.1 0.114
-
 pH 7.2, 22°C Oryctolagus cuniculus Caffeine
2.4.1.1 0.132
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-(2,4-dichlorobenzyl)pyrazolo[4,3-b]olean-12-en-28-oate