Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wang, X.; Feith, D.J.; Welsh, P.; Coleman, C.S.; Lopez, C.; Woster, P.M.; OBrien, T.G.; Pegg, A.E.
    Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis (2007), Carcinogenesis, 28, 2404-2411.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.57 N1,N11-bis(ethyl)-norspermidine increases SSAT activity, tumor regression analyzed in tumor-bearing transgenic mice expressing SSAT, tumor regression not enhanced by treatment with Mus musculus

Application

EC Number Application Comment Organism
2.3.1.57 medicine tumor progression in transgenic mouse lines overexpressing SSAT protein and susceptibility to skin carcinogenesis analyzed Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine Mus musculus
-
CoA + N1-acetylspermidine
-
?
2.3.1.57 acetyl-CoA + spermine Mus musculus
-
CoA + N1-acetylspermine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Mus musculus P48026 keratin 6 (K6)-spermidine/spermine N1-acetyltransferase (SSAT) transgenic mice, B6D2F2 background
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 skin overexpressed in transgenic mice Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.57 additional information
-
tumor progression in transgenic mice expressing SSAT depends on elevated activity of ornithine decarboxylase (ODC) and on increased putrescine levels, strategy to modulate polyamine levels through the inhibition of ornithine decarboxylase (ODC) activity or polyamine uptake, but not via increased SSAT expression for cancer chemoprevention Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine
-
Mus musculus CoA + N1-acetylspermidine
-
?
2.3.1.57 acetyl-CoA + spermine
-
Mus musculus CoA + N1-acetylspermine
-
?
2.3.1.57 acetyl-CoA + spermine pharmacologic and genetic manipulation of keratin 6 (K6)-spermidine/spermine N1-acetyltransferase (SSAT) transgenic mice subjected to carcinogenesis Mus musculus CoA + N1-acetylspermine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.57 spermidine/spermine N1-acetyltransferase
-
Mus musculus
2.3.1.57 SSAT
-
Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.57 7.5
-
activity assay at Mus musculus