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Literature summary extracted from
- The conformational coupling and translocation mechanism of vitamin B12 ATP-binding cassette transporter BtuCD (2008), Biophys. J., 94, 612-621.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.6.2.8 | periplasm | - |
Escherichia coli | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.8 | ATP + H2O + vitamin B12/out | Escherichia coli | - |
ADP + phosphate + vitamin B12/in | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.6.2.8 | Escherichia coli | P06611 | encoded by btuD gene; K12 | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.8 | additional information | - |
intrinsic flexibility of isolated BtuC and BtuD dimers evaluated, conformational movement of intact BtuCD transporter studied in the context of conformational coupling between BtuC and BtuD, effect of BtuF association on the transporter conformational movement discussed | Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.8 | ATP + H2O + vitamin B12/out | - |
Escherichia coli | ADP + phosphate + vitamin B12/in | - |
? | |
| 7.6.2.8 | ATP + H2O + vitamin B12/out | elastic normal mode analysis of BtuCD performed, mechanism of vitamin B12 transport cycle proposed | Escherichia coli | ADP + phosphate + vitamin B12/in | - |
? | |
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Release 2023.1 (January 2023)
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