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Literature summary extracted from

  • Sonne, J.; Kandt, C.; Peters, G.H.; Hansen, F.Y.; Jensen, M.?.; Tieleman, D.P.
    Simulation of the coupling between nucleotide binding and transmembrane domains in the ATP binding cassette transporter BtuCD (2007), Biophys. J., 92, 2727-2734.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.8 ATP + H2O + vitamin B12/out Escherichia coli
-
 ADP + phosphate + vitamin B12/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.8 Escherichia coli P37028
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.6.2.8 additional information
-
 perturbed anisotropic network model and molecular dynamics simulations applied, essential dynamics sampling and cavity and pathway analysis, structural response of BtuC protein quantified in terms of X-shifts shown, transport model discussed Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.8 ATP + H2O + vitamin B12/out
-
 Escherichia coli ADP + phosphate + vitamin B12/in
-
 ?
7.6.2.8 ATP + H2O + vitamin B12/out nucleotide binding and release in the vitamin B12 importer BtuCD analyzed, perturbed elastic network calculations and biased molecular dynamics simulations applied, peristaltic forces suggested to exclude vitamin B12 from the transporter pore Escherichia coli ADP + phosphate + vitamin B12/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.8 BtuF
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 Escherichia coli