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Literature summary extracted from
- Theoretical calculation of the binding free energies for pyruvate dehydrogenase E1 binding with ligands (2007), Bioorg. Med. Chem. Lett., 17, 5186-5190.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.4.1 | Methylacetylphosphonate | - |
Escherichia coli |  |
| 1.2.4.1 | thiamine thiazolone diphosphate | - |
Escherichia coli | |
| 1.2.4.1 | thiamine thiothiazolone diphosphate | - |
Escherichia coli | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.4.1 | Mg2+ | activates | Escherichia coli | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.4.1 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.4.1 | pyruvate + CoA + NAD+ | - |
Escherichia coli | acetyl-CoA + CO2 + NADH | - |
? | |
| 1.2.4.1 | pyruvate + lipoamide | - |
Escherichia coli | S-acetyldihydrolipoamide + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.2.4.1 | PDHc E1 | - |
Escherichia coli |
| 1.2.4.1 | pyruvate dehydrogenase multienzyme complex E1 | - |
Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.4.1 | NAD+ | - |
Escherichia coli | |
| 1.2.4.1 | thiamine diphosphate | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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