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Literature summary extracted from

  • Shin, E.S.; Park, J.; Shin, J.M.; Cho, D.; Cho, S.Y.; Shin, D.W.; Ham, M.; Kim, J.B.; Lee, T.R.
    Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme (2008), Bioorg. Med. Chem., 16, 3580-3586.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 (-)-catechin gallate NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase Mus musculus
1.1.1.44 (-)-epicatechin gallate
-
 Mus musculus
1.1.1.44 (-)-epigallocatechin NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase Mus musculus
1.1.1.44 (-)-epigallocatechin gallate NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase Mus musculus
1.1.1.44 (-)-gallocatechin gallate NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase Mus musculus
1.1.1.44 additional information not inhibited by ungallated catechins like (-)-epigallocatechin, (-)-gallocatechin, (-)-epicatechin, (-)-catechin, and dehydroepiandrosterone Mus musculus
1.1.1.49 (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
-
 Saccharomyces cerevisiae
1.1.1.49 (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
-
 Saccharomyces cerevisiae
1.1.1.49 (2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
-
 Saccharomyces cerevisiae
1.1.1.49 (2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
-
 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Mus musculus
-
-
-
1.1.1.49 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 3T3-L1 cell
-
 Mus musculus
-
1.1.1.44 adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Mus musculus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Mus musculus
1.1.1.44 6PGD
-
 Mus musculus
1.1.1.49 G6PD
-
 Saccharomyces cerevisiae
1.1.1.49 glucose-6-phosphate dehydrogenase
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.44 0.00072
-
 in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C Mus musculus (-)-epigallocatechin gallate
1.1.1.44 0.00121
-
 in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C Mus musculus (-)-epicatechin gallate
1.1.1.44 0.00128
-
 in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C Mus musculus (-)-catechin gallate
1.1.1.44 0.00145
-
 in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C Mus musculus (-)-gallocatechin gallate
1.1.1.49 0.00018
-
-
 Saccharomyces cerevisiae (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
1.1.1.49 0.00023
-
-
 Saccharomyces cerevisiae (2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
1.1.1.49 0.00024
-
-
 Saccharomyces cerevisiae (2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
1.1.1.49 0.00025
-
-
 Saccharomyces cerevisiae (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate