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Literature summary extracted from

  • Li, M.; Allen, A.; Smith, T.J.
    High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors (2007), Biochemistry, 46, 15089-15102.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.1.2 ADP ADP can reverse inhibition Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.2 3,3'-[(2-bromobenzene-1,4-diyl)di(E)ethene-2,1-diyl]bis(6-hydroxybenzoic acid) i.e. BSB Bos taurus
1.4.1.2 ATP/GTP-competitive inhibitor of casein kinase-2
-
 Bos taurus
1.4.1.2 aurintricarboxylic acid
-
 Bos taurus
1.4.1.2 BH3I-2
-
 Bos taurus
1.4.1.2 bithionol
-
 Bos taurus
1.4.1.2 Calmidazolium
-
 Bos taurus
1.4.1.2 diethylstilbestrol
-
 Bos taurus
1.4.1.2 epicatechin
-
 Bos taurus
1.4.1.2 epicatechin-3-monogallate
-
 Bos taurus
1.4.1.2 epicatechin-monogallate
-
 Bos taurus
1.4.1.2 epigallocatechin
-
 Bos taurus
1.4.1.2 epigallocatechin-3,5-digallate
-
 Bos taurus
1.4.1.2 epigallocatechin-3-gallate
-
 Bos taurus
1.4.1.2 erythrosin B
-
 Bos taurus
1.4.1.2 ethaverine hydrochloride
-
 Bos taurus
1.4.1.2 gallic acid
-
 Bos taurus
1.4.1.2 GW-5074
-
 Bos taurus
1.4.1.2 Hexachlorophene
-
 Bos taurus
1.4.1.2 leoidin
-
 Bos taurus
1.4.1.2 metergoline
-
 Bos taurus
1.4.1.2 suloctidil
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.1.2 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.2 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.2 L-glutamate + H2O + NAD+
-
 Bos taurus 2-oxoglutarate + NH3 + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.1.2 GDH
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.2 NAD+
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.1.2 0.0005
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus epicatechin-3-monogallate
1.4.1.2 0.0005
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus epigallocatechin-3-monogallate
1.4.1.2 0.0012
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus aurintricarboxylic acid
1.4.1.2 0.0015
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus GW-5074
1.4.1.2 0.0017
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus diethylstilbestrol
1.4.1.2 0.0017
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus Hexachlorophene
1.4.1.2 0.0037
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus BH3I-2
1.4.1.2 0.0055
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus bithionol
1.4.1.2 0.0064
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus 3,3'-[(2-bromobenzene-1,4-diyl)di(E)ethene-2,1-diyl]bis(6-hydroxybenzoic acid)
1.4.1.2 0.0077
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus Calmidazolium
1.4.1.2 0.0138
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus suloctidil
1.4.1.2 0.0158
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus ATP/GTP-competitive inhibitor of casein kinase-2
1.4.1.2 0.0328
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus metergoline
1.4.1.2 0.05
-
 IC50 above 0.05 mM, in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus erythrosin B
1.4.1.2 0.08
-
 in 0.1 M sodium phosphate buffer, pH 8.0, using 50 mM sodium glutamate and 0.2 mM NAD+ Bos taurus gallic acid