Literature summary extracted from

Hogarth, L.A.; Redfern, C.P.; Teodoridis, J.M.; Hall, A.G.; Anderson, H.; Case, M.C.; Coulthard, S.A.
The effect of thiopurine drugs on DNA methylation in relation to TPMT expression (2008), Biochem. Pharmacol., 76, 1024-1035.

Application

EC Number	Application	Comment	Organism
2.1.1.67	medicine	thiopurine methyltransferase metabolises thiopurine drugs and influences their cytotoxic activity	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.67	S-adenosyl-L-methionine + a thiopurine	Homo sapiens	-	S-adenosyl-L-homocysteine + a thiopurine S-methylether	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.67	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.67	embryonic kidney cell line	embryonic kidney cell line with inducible thiopurine methyltransferase	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.67	S-adenosyl-L-methionine + 6-mercaptopurine	-	Homo sapiens	?	-	?
2.1.1.67	S-adenosyl-L-methionine + 6-thioguanine	-	Homo sapiens	?	-	?
2.1.1.67	S-adenosyl-L-methionine + a thiopurine	-	Homo sapiens	S-adenosyl-L-homocysteine + a thiopurine S-methylether	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.67	thiopurine methyltransferase	-	Homo sapiens
2.1.1.67	TPMT	-	Homo sapiens

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Release 2023.1 (January 2023)