Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Piacenza, L.; Peluffo, G.; Alvarez, M.N.; Kelly, J.M.; Wilkinson, S.R.; Radi, R.
    Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite (2008), Biochem. J., 410, 359-368.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.24 C52A parasites expressing CPX C52A fail to confer peroxynitrite resistance Trypanosoma cruzi
1.11.1.24 C81A parasites expressing MPX C81A fail to confer peroxynitrite resistance Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.24 H2O2
-
 Trypanosoma cruzi
1.11.1.24 peroxynitrite
-
 Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.24 cytosol CPX Trypanosoma cruzi 5829
-
1.11.1.24 mitochondrion MPX Trypanosoma cruzi 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.24 Trypanosoma cruzi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.24 epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.24 peroxynitrite + H2O2 CPX and MPX catalytically reduce peroxynitrite to nitrite through a fast-reacting thiol group located at the peroxidatic cysteine residue (Cys52 and Cys81 in CPX and MPX respectively), thus acting as tryparedoxin/peroxynitrite oxidoreductases Trypanosoma cruzi nitrite + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.24 CPX belongs to the 2-cysteine peroxiredoxin family Trypanosoma cruzi
1.11.1.24 MPX
-
 Trypanosoma cruzi
1.11.1.24 tryparedoxin peroxidase
-
 Trypanosoma cruzi
1.11.1.24 tryparedoxin/peroxynitrite oxidoreductase
-
 Trypanosoma cruzi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.11.1.24 0.294
-
 MPX, at 28°C Trypanosoma cruzi H2O2
1.11.1.24 0.3
-
 CPX, at 28°C Trypanosoma cruzi H2O2
1.11.1.24 0.4
-
 MPX, at 28°C Trypanosoma cruzi peroxynitrite
1.11.1.24 0.48
-
 CPX, at 28°C Trypanosoma cruzi peroxynitrite