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Literature summary extracted from
- Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals (2007), Biochem. J., 407, 321-329.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.4.11 | - |
Escherichia coli |
| 1.8.4.11 | overexpression of bovine MsrA in Drosophila extends lifespan by 70%, as well as increased resistance to paraquat-induced oxidative stress | Bos taurus |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.8.4.11 | - |
Escherichia coli |
| 1.8.4.11 | - |
Bos taurus |
| 1.8.4.11 | - |
Mycobacterium tuberculosis |
| 1.8.4.11 | - |
Populus trichocarpa |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.4.11 | mitochondrion | - |
Mus musculus | 5739 | - |
| 1.8.4.11 | plastid | - |
Populus trichocarpa | 9536 | - |
| 1.8.4.12 | endoplasmic reticulum | MsrB3 has consecutive endoplasmic reticulum and mitochondrial targeting signals at the N-terminus. This protein is targeted to the endoplasmic reticulum, and the function of the mitochondrial signal appears to be masked by the endoplasmic reticulum signal peptide | Mus musculus | 5783 | - |
| 1.8.4.12 | endoplasmic reticulum | MsrB3A contains an endoplasmic reticulum signal peptide at the N-terminus and an endoplasmic reticulum retention signal at the C-terminus, and is targeted to the endoplasmic reticulum | Homo sapiens | 5783 | - |
| 1.8.4.12 | mitochondrion | MsrB3B contains a different signal peptide at the N-terminus and is targeted to mitochondria | Homo sapiens | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.11 | selenium | selenocysteine-containing | Escherichia coli |  |
| 1.8.4.11 | selenium | selenocysteine-containing | Homo sapiens | |
| 1.8.4.11 | selenium | selenocysteine-containing | Bos taurus | |
| 1.8.4.11 | selenium | selenocysteine-containing | Neisseria gonorrhoeae | |
| 1.8.4.11 | selenium | selenocysteine-containing | Neisseria meningitidis | |
| 1.8.4.11 | selenium | selenocysteine-containing | Mycobacterium tuberculosis | |
| 1.8.4.11 | selenium | selenocysteine-containing | Populus trichocarpa | |
| 1.8.4.11 | selenium | selenocysteine-containing | Mus musculus | |
| 1.8.4.12 | selenium | selenocysteine-containing | Drosophila melanogaster | |
| 1.8.4.12 | selenium | selenocysteine-containing | Neisseria meningitidis | |
| 1.8.4.12 | selenium | selenocysteine-containing | Homo sapiens | |
| 1.8.4.12 | selenium | selenocysteine-containing | Mus musculus | |
| 1.8.4.12 | selenium | selenocysteine-containing | Bacillus subtilis | |
| 1.8.4.12 | Zinc | zinc-containing enzyme | Drosophila melanogaster | |
| 1.8.4.12 | Zinc | zinc-containing enzyme | Homo sapiens | |
| 1.8.4.12 | Zinc | zinc-containing enzyme | Mus musculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | Bos taurus | - |
- |
- |
| 1.8.4.11 | Escherichia coli | - |
- |
- |
| 1.8.4.11 | Homo sapiens | - |
- |
- |
| 1.8.4.11 | Mus musculus | Q9D6Y7 | - |
- |
| 1.8.4.11 | Mycobacterium tuberculosis | - |
- |
- |
| 1.8.4.11 | Neisseria gonorrhoeae | - |
- |
- |
| 1.8.4.11 | Neisseria meningitidis | - |
- |
- |
| 1.8.4.11 | Populus trichocarpa | - |
- |
- |
| 1.8.4.12 | Bacillus subtilis | P54155 | - |
- |
| 1.8.4.12 | Drosophila melanogaster | - |
- |
- |
| 1.8.4.12 | Homo sapiens | Q8IXL7 | - |
- |
| 1.8.4.12 | Mus musculus | Q8BU85 | - |
- |
| 1.8.4.12 | Neisseria meningitidis | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | skin | up-regulation of the protein in response to UV irradiation and hydrogen peroxide, suggesting a role of MsrA in photoprotection in epidermis | Homo sapiens | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | MsrA | - |
Escherichia coli |
| 1.8.4.11 | MsrA | - |
Homo sapiens |
| 1.8.4.11 | MsrA | - |
Bos taurus |
| 1.8.4.11 | MsrA | - |
Mycobacterium tuberculosis |
| 1.8.4.11 | MsrA | - |
Populus trichocarpa |
| 1.8.4.11 | MsrA | - |
Mus musculus |
| 1.8.4.11 | MsrA/MsrB | bifunctional enzyme EC 1.8.4.11/EC 1.8.4.12 | Neisseria gonorrhoeae |
| 1.8.4.11 | MsrA/MsrB | bifunctional enzyme EC 1.8.4.11/EC 1.8.4.12 | Neisseria meningitidis |
| 1.8.4.12 | MsrA/MsrB | bifunctional enzyme EC 1.8.4.11/EC 1.8.4.12 | Neisseria meningitidis |
| 1.8.4.12 | MsrB | - |
Drosophila melanogaster |
| 1.8.4.12 | MsrB | - |
Bacillus subtilis |
| 1.8.4.12 | MsrB3 | - |
Mus musculus |
| 1.8.4.12 | MsrB3 | MsrB3 occurs in two forms, MsrB3A and MsrB3B, owing to alternative first exon splicing | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.12 | additional information | thioredoxin independent | Homo sapiens |
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