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Literature summary extracted from

  • Takazawa, C.; Fujimoto, K.; Homma, D.; Sumi-Ichinose, C.; Nomura, T.; Ichinose, H.; Katoh, S.
    A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice - as a mouse model for Parkinsons disease (2008), Biochem. Biophys. Res. Commun., 367, 787-792.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.153 additional information construction of enzyme knockout mice, the SPR null mice show partial lethality and highly reduced tetrahydrobiopterin content, e.g. less than 10% of wild-type levels in the brain, and monoamine contents. Spr-null mice exhibit severe monoamine deficiencies and a tremor-like phenotype after weaning, pteridine contents in the tissues of Spr mutant mice, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH Mus musculus
-
 tetrahydrobiopterin + NADP+
-
 r
1.1.1.153 sepiapterin + NADPH + H+ Mus musculus
-
 7,8-dihydrobiopterin + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Mus musculus
-
 wild-type C57BL/6J mice
-
1.14.16.2 Mus musculus
-
 sepiapterin reductase-null mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 brain
-
 Mus musculus
-
1.14.16.2 adrenal gland
-
 Mus musculus
-
1.14.16.2 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
 Mus musculus tetrahydrobiopterin + NADP+
-
 r
1.1.1.153 sepiapterin + NADPH + H+
-
 Mus musculus 7,8-dihydrobiopterin + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 tyrosine hydroxylase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.14.16.2 Mus musculus the amount of tyrosine hydroxylase protein in the brain of sepiapterin reductase-null mice is less than 10% of wild type, while tyrosine hydroxylase protein in the adrenal gland is not altered down