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Literature summary extracted from
- Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 A (2008), Biochem. Biophys. Res. Commun., 366, 15-22.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.99.66 | fragment consisting of residues 172-833, expression as glutathione S-transferase fusion protein in Escherichia coli | Homo sapiens |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.14.99.66 | in complex with inhibitor tranylcypromine, diffraction to 2.25 A. In the inhibitor-free structure, a water molecule forms a hydrogen bond with the flavin N(5) atom and Lys661. The LSD1-tranylcypromine complex is not completely composed of the five-membered adduct, but partially contains an intermediate | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.66 | Homo sapiens | O60341 | isoform LSD1 | - |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.66 | FAD | - |
Homo sapiens |  |
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Release 2023.1 (January 2023)
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