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Literature summary extracted from

  • Famer, D.; Meaney, S.; Mousavi, M.; Nordberg, A.; Bjoerkhem, I.; Crisby, M.
    Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway (2007), Biochem. Biophys. Res. Commun., 359, 46-50.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.25 additional information polymorphisms within the CYP46A1 gene are associated with Alzheimer’s disease incidence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Homo sapiens a major pathway for excretion of excess cholesterol from the brain, polymorphisms within the CYP46A1 gene are associated with Alzheimer’s disease incidence. The ratio between 24S-OHC and 27-OHC is of importance for the generation of amyloid in the brain, overview (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Homo sapiens
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 gene CYP46A1
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 central nervous system almost exclusive expression of gene CYP46A1 Homo sapiens
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1.14.14.25 neuroblastoma cell
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 Homo sapiens
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1.14.14.25 SH-SY5Y cell
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 a major pathway for excretion of excess cholesterol from the brain, polymorphisms within the CYP46A1 gene are associated with Alzheimer’s disease incidence. The ratio between 24S-OHC and 27-OHC is of importance for the generation of amyloid in the brain, overview Homo sapiens (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.25 additional information (24S)-24-hydroxycholesterol activates alpha- and beta-secretases, while (27S)-27-hydroxycholesterol inhibits them, overview Homo sapiens ?
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 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 NADPH
-
 Homo sapiens