Literature summary extracted from

Lin, C.C.; Liu, X.M.; Peyton, K.; Wang, H.; Yang, W.C.; Lin, S.J.; Durante, W.
Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1 (2008), Arterioscler. Thromb. Vasc. Biol., 28, 739-745.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.14.14.18	additional information	far infrared irradiation induces HO-1 protein, mRNA and promoter activity through heat stress which activates the antioxidant responsive element/NF-E2-related factor-2 complex, overview	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.14.18	tin protoporphyrin IX	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.18	heme + AH2 + O2	Homo sapiens	inhibition or selective knockdown of HO-1 has anti-inflammatory effects via bilirubin, overview	biliverdin + Fe2+ + CO + A + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.18	Homo sapiens	P09601	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.14.18	endothelial cell	-	Homo sapiens	-
1.14.14.18	HUVEC cell	i.e. human umbilical vein endothelial cell	Homo sapiens	-
1.14.14.18	umbilical vein	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.18	heme + AH2 + O2	-	Homo sapiens	biliverdin + Fe2+ + CO + A + H2O	-	?
1.14.14.18	heme + AH2 + O2	inhibition or selective knockdown of HO-1 has anti-inflammatory effects via bilirubin, overview	Homo sapiens	biliverdin + Fe2+ + CO + A + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.18	heme oxygenase-1	-	Homo sapiens
1.14.14.18	HO-1	-	Homo sapiens

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Release 2023.1 (January 2023)