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Literature summary extracted from

  • Parini, P.; Gustafsson, U.; Davis, M.A.; Larsson, L.; Einarsson, C.; Wilson, M.; Rudling, M.; Tomoda, H.; Omura, S.; Sahlin, S.; Angelin, B.; Rudel, L.L.; Eriksson, M.
    Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2 (2008), Arterioscler. Thromb. Vasc. Biol., 28, 1200-1206.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.26 medicine statin treatment reduces ACAT2 activity in human liver and this effect, in combination with a reduced ApoE expression, may contribute to the favorable lowering of VLDL cholesterol seen in addition to the LDL lowering during statin treatment Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.26 50000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.26 0.0000293
-
 ACAT2 activity, effect on ChSI on hepatic ACAT2 expression, high cholesterol synthesis inhibition, high ChSI Homo sapiens
2.3.1.26 0.0000333
-
 ACAT2 activity, effect on ChSI on hepatic ACAT2 expression, low cholesterol synthesis inhibition, low ChSI Homo sapiens
2.3.1.26 0.0000377
-
 ACAT2 activity, effect on cholesterol synthesis inhibition on hepatic ACAT2 expression, placebo Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT2
-
 Homo sapiens
2.3.1.26 acyl-CoA:cholesterol acyltransferase 2
-
 Homo sapiens