Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fujiwara, Y.; Kiyota, N.; Hori, M.; Matsushita, S.; Iijima, Y.; Aoki, K.; Shibata, D.; Takeya, M.; Ikeda, T.; Nohara, T.; Nagai, R.
    Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT (2007), Arterioscler. Thromb. Vasc. Biol., 27, 2400-2406.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.26 medicine the study provides evidence that purified esculeogenin A significantly suppresses the activity of ACAT protein and leads to reduction of atherogenesis Mus musculus
2.3.1.26 medicine the study provides evidence that purified esculeogenin A significantly suppresses the activity of ACAT protein and leads to reduction of atherogenesis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 CI976
-
 Homo sapiens
2.3.1.26 CI976
-
 Mus musculus
2.3.1.26 esculeogenin A
-
 Homo sapiens
2.3.1.26 esculeogenin A
-
 Mus musculus
2.3.1.26 esculeoside A
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 rough endoplasmic reticulum
-
 Mus musculus 5791
-
2.3.1.26 rough endoplasmic reticulum
-
 Homo sapiens 5791
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Mus musculus
-
 CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens
-
-
-
2.3.1.26 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.26 microsomes prepared from monocyte-derived macrophagesare are used as an enzyme source Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 intestine
-
 Mus musculus
-
2.3.1.26 liver
-
 Mus musculus
-
2.3.1.26 macrophage monocyte-derived macrophage Homo sapiens
-
2.3.1.26 peritoneal macrophage
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.26 0.000081
-
 ACAT activity in liver, 100 mg/kg/day esculeoside A Mus musculus
2.3.1.26 0.000088
-
 ACAT activity in peritoneal macrophage, 100 mg/kg/day esculeoside A Mus musculus
2.3.1.26 0.000144
-
 ACAT activity in intestine, 100 mg/kg/day esculeoside A Mus musculus
2.3.1.26 0.000144
-
 ACAT activity in intestine, control Mus musculus
2.3.1.26 0.00015
-
 ACAT activity in peritoneal macrophage, control Mus musculus
2.3.1.26 0.000156
-
 ACAT activity in liver, control Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Mus musculus CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT
-
 Mus musculus
2.3.1.26 ACAT
-
 Homo sapiens
2.3.1.26 acyl-coenzymeA:cholesterol acyl-transferase
-
 Mus musculus
2.3.1.26 acyl-coenzymeA:cholesterol acyl-transferase
-
 Homo sapiens
2.3.1.26 hACAT
-
 Homo sapiens