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Literature summary extracted from

  • Krumova, E.; Dolashki, A.; Pashova, S.; Dolashka-Angelova, P.; Stevanovic, S.; Hristova, R.; Stefanova, L.; Voelter, W.; Angelova, M.
    Unusual location and characterization of Cu/Zn-containing superoxide dismutase from filamentous fungus Humicola lutea (2008), Arch. Microbiol., 189, 121-130.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 cyanide the isoenzyme Cu/Zn-SOD is cyanide-sensitive, while the Mn-SOD is not Humicola lutea

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 cytosol isozyme Cu/Zn-SOD Humicola lutea 5829
-
1.15.1.1 mitochondrial intermembrane space isoenzyme Cu/Zn-SOD Humicola lutea 5758
-
1.15.1.1 mitochondrial matrix isoenzyme Mn-SOD, specifically Humicola lutea 5759
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Cu2+ isozyme Cu/Zn-SOD Humicola lutea
1.15.1.1 Mn2+ isozyme Mn-SOD Humicola lutea
1.15.1.1 Zn2+ isozyme Cu/Zn-SOD Humicola lutea

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.15.1.1 15912
-
 2 * 15912, mass spectrometry Humicola lutea
1.15.1.1 32000
-
 native PAGE Humicola lutea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 O2.- + H+ Humicola lutea
-
 O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ Humicola lutea 103
-
 O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Humicola lutea
-
 isozymes Cu/Zn-SOD and Mn-SOD
-
1.15.1.1 Humicola lutea 103
-
 isozymes Cu/Zn-SOD and Mn-SOD
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.15.1.1 glycoprotein Cu/Zn-SOD from mitochondrial intermembrane space and cytosol is glycosylated Humicola lutea

Purification (Commentary)

EC Number Purification (Comment) Organism
1.15.1.1 native Cu/Zn-SOD and Mn-SOD partially by subcellular fractionation, further purfication of mitochondrial Cu/Zn-SOD by anion exchange chromatography and, for analysis, by RP-HPLC Humicola lutea

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.15.1.1 31.24
-
 mitochondrial Mn-SOD Humicola lutea
1.15.1.1 39.64
-
 cytosolic Cu/Zn-SOD Humicola lutea
1.15.1.1 40.21
-
 mitochondrial Cu/Zn-SOD Humicola lutea

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2.- + H+
-
 Humicola lutea O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+
-
 Humicola lutea 103 O2 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.15.1.1 dimer 2 * 15912, mass spectrometry Humicola lutea

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 Cu/Zn-SOD
-
 Humicola lutea
1.15.1.1 Cu/Zn-superoxide dismutase
-
 Humicola lutea
1.15.1.1 Mn-SOD
-
 Humicola lutea