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Literature summary extracted from
- Effects of the compounds 2-methoxynaphthoquinone, 2-propoxynaphthoquinone, and 2-isopropoxynaphthoquinone on ecdysone 20-monooxygenase activity (2007), Arch. Insect Biochem. Physiol., 66, 45-52.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.22 | 2-isopropoxy-1,4-naphthoquinone | synthetic compound | Aedes aegypti |  |
| 1.14.99.22 | 2-isopropoxy-1,4-naphthoquinone | synthetic compound | Drosophila melanogaster | |
| 1.14.99.22 | 2-isopropoxy-1,4-naphthoquinone | synthetic compound | Manduca sexta | |
| 1.14.99.22 | 2-methoxy-1,4-naphthoquinone | isolated from the leaves of Impatiens glandulifera | Aedes aegypti | |
| 1.14.99.22 | 2-methoxy-1,4-naphthoquinone | isolated from the leaves of Impatiens glandulifera | Drosophila melanogaster | |
| 1.14.99.22 | 2-methoxy-1,4-naphthoquinone | isolated from the leaves of Impatiens glandulifera | Manduca sexta | |
| 1.14.99.22 | 2-propoxy-1,4-naphthoquinone | synthetic compound | Aedes aegypti | |
| 1.14.99.22 | 2-propoxy-1,4-naphthoquinone | synthetic compound | Drosophila melanogaster | |
| 1.14.99.22 | 2-propoxy-1,4-naphthoquinone | synthetic compound | Manduca sexta | |
| 1.14.99.22 | additional information | inhibition profiles | Aedes aegypti | |
| 1.14.99.22 | additional information | inhibition profiles | Drosophila melanogaster | |
| 1.14.99.22 | additional information | inhibition profiles | Manduca sexta |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.22 | Fe2+ | a cytochrome P450-dependent hydroxylase | Drosophila melanogaster | |
| 1.14.99.22 | Fe2+ | a cytochrome P450-dependent hydroxylase | Aedes aegypti | |
| 1.14.99.22 | Fe2+ | a cytochrome P450-dependent hydroxylase | Manduca sexta | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.22 | ecdysone + AH2 + O2 | Drosophila melanogaster | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | 20-hydroxyecdysone + A + H2O | - |
? | |
| 1.14.99.22 | ecdysone + AH2 + O2 | Aedes aegypti | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | 20-hydroxyecdysone + A + H2O | - |
? | |
| 1.14.99.22 | ecdysone + AH2 + O2 | Manduca sexta | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | 20-hydroxyecdysone + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.22 | Aedes aegypti | - |
females | - |
| 1.14.99.22 | Drosophila melanogaster | - |
- |
- |
| 1.14.99.22 | Manduca sexta | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.22 | abdomen | - |
Aedes aegypti | - |
| 1.14.99.22 | fat body | from fifth instar larvae | Manduca sexta | - |
| 1.14.99.22 | larva | fifth instar larvae | Manduca sexta | - |
| 1.14.99.22 | larva | wandering stage third instar larvae | Drosophila melanogaster | - |
| 1.14.99.22 | midgut | from fifth instar larvae | Manduca sexta | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.22 | additional information | - |
- |
Drosophila melanogaster |
| 1.14.99.22 | additional information | - |
- |
Aedes aegypti |
| 1.14.99.22 | additional information | - |
- |
Manduca sexta |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.22 | ecdysone + AH2 + O2 | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | Drosophila melanogaster | 20-hydroxyecdysone + A + H2O | - |
? | |
| 1.14.99.22 | ecdysone + AH2 + O2 | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | Aedes aegypti | 20-hydroxyecdysone + A + H2O | - |
? | |
| 1.14.99.22 | ecdysone + AH2 + O2 | the enzyme is responsible for the conversion of the molting hormone ecdysone to its more physiologically active metabolite, 20-hydroxyecdysone | Manduca sexta | 20-hydroxyecdysone + A + H2O | - |
? | |
| 1.14.99.22 | ecdysone + NADPH + H+ + O2 | - |
Drosophila melanogaster | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
| 1.14.99.22 | ecdysone + NADPH + H+ + O2 | - |
Aedes aegypti | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
| 1.14.99.22 | ecdysone + NADPH + H+ + O2 | - |
Manduca sexta | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.99.22 | E-20-M | - |
Drosophila melanogaster |
| 1.14.99.22 | E-20-M | - |
Aedes aegypti |
| 1.14.99.22 | E-20-M | - |
Manduca sexta |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.22 | 7.5 | - |
assay at | Drosophila melanogaster |
| 1.14.99.22 | 7.5 | - |
assay at | Aedes aegypti |
| 1.14.99.22 | 7.5 | - |
assay at | Manduca sexta |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.22 | cytochrome P450 | a cytochrome P450-dependent hydroxylase | Drosophila melanogaster | |
| 1.14.99.22 | cytochrome P450 | a cytochrome P450-dependent hydroxylase | Aedes aegypti | |
| 1.14.99.22 | cytochrome P450 | a cytochrome P450-dependent hydroxylase | Manduca sexta | |
| 1.14.99.22 | NADPH | - |
Drosophila melanogaster | |
| 1.14.99.22 | NADPH | - |
Aedes aegypti | |
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