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Literature summary extracted from

  • Lee, T.H.; Kim, H.Y.
    An anaerobic bacterial MsrB model reveals catalytic mechanisms, advantages, and disadvantages provided by selenocysteine and cysteine in reduction of methionine-R-sulfoxide (2008), Arch. Biochem. Biophys., 478, 175-180.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.12 expression of the wild-type and mutant forms of MsrB in Escherichia coli Clostridium sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.4.12 selenium the selenocysteine-containing Clostridium MsrB form exhibits 100fold higher activity than its Cys-containing form, revealing that selenocysteine provides the catalytic advantage of higher activity. A resolving Cys is required for the thioredoxin-dependent recycling process of the selenocysteine-containing form. Thus, thioredoxin can reduce the selenylsulfide bond, but its Trx-dependent recycling process is much less efficient compared to that for the disulfide bond in the Cys-containing form, demonstrating an obvious catalytic disadvantage Clostridium sp.

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Clostridium sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.12
-
 Clostridium sp.

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 MsrB
-
 Clostridium sp.