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Literature summary extracted from

  • Hrabak, A.; Bajor, T.; Meszaros, G.
    The inhibitory effect of various indolyl amino acid derivatives on arginase activity in macrophages (2008), Amino Acids, 34, 293-300.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.1 2-(1H-indol-3-yl)ethanol
-
 Bos taurus
3.5.3.1 2-(1H-indol-3-yl)ethanol
-
 Mus musculus
3.5.3.1 5-hydroxy-L-tryptophan
-
 Bos taurus
3.5.3.1 5-hydroxy-L-tryptophan
-
 Mus musculus
3.5.3.1 5-hydroxytryptamine
-
 Bos taurus
3.5.3.1 5-hydroxytryptamine
-
 Mus musculus
3.5.3.1 D-tryptophan
-
 Bos taurus
3.5.3.1 D-tryptophan
-
 Mus musculus
3.5.3.1 imidazole-3-lactate
-
 Bos taurus
3.5.3.1 imidazole-3-lactate
-
 Mus musculus
3.5.3.1 indole
-
 Bos taurus
3.5.3.1 indole
-
 Mus musculus
3.5.3.1 indole-3-L-lactic acid
-
 Bos taurus
3.5.3.1 indole-3-L-lactic acid
-
 Mus musculus
3.5.3.1 indole-propionic acid
-
 Mus musculus
3.5.3.1 Indolepropionic acid
-
 Bos taurus
3.5.3.1 L-tryptophan
-
 Bos taurus
3.5.3.1 L-tryptophan
-
 Mus musculus
3.5.3.1 N-acetyl-5-hydroxytryptamine
-
 Bos taurus
3.5.3.1 N-acetyl-5-hydroxytryptamine
-
 Mus musculus
3.5.3.1 tryptamine
-
 Bos taurus
3.5.3.1 tryptamine
-
 Mus musculus
3.5.3.1 tyramine
-
 Bos taurus
3.5.3.1 tyramine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.1 L-arginine + H2O Mus musculus
-
 L-ornithine + urea
-
 ?
3.5.3.1 L-arginine + H2O Bos taurus
-
 L-ornithine + urea
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.1 Bos taurus
-
-
-
3.5.3.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.1 liver
-
 Bos taurus
-
3.5.3.1 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.1 L-arginine + H2O
-
 Mus musculus L-ornithine + urea
-
 ?
3.5.3.1 L-arginine + H2O
-
 Bos taurus L-ornithine + urea
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.3.1 2.8
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus Indolepropionic acid
3.5.3.1 2.8
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus Indolepropionic acid
3.5.3.1 3.2
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus tryptamine
3.5.3.1 3.3
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus 5-hydroxytryptamine
3.5.3.1 3.4
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus tryptamine
3.5.3.1 3.4
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus indole-3-L-lactic acid
3.5.3.1 3.6
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus 5-hydroxy-L-tryptophan
3.5.3.1 3.6
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus 5-hydroxytryptamine
3.5.3.1 3.6
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus indole-3-L-lactic acid
3.5.3.1 3.9
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus 5-hydroxy-L-tryptophan
3.5.3.1 4.8
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus 2-(1H-indol-3-yl)ethanol
3.5.3.1 5.3
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus 2-(1H-indol-3-yl)ethanol
3.5.3.1 7.5
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus L-tryptophan
3.5.3.1 8.4
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus L-tryptophan
3.5.3.1 8.4
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus D-tryptophan
3.5.3.1 10
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus D-tryptophan
3.5.3.1 20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Mus musculus tyramine
3.5.3.1 20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Bos taurus tyramine
3.5.3.1 20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Mus musculus indole
3.5.3.1 20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Bos taurus indole
3.5.3.1 20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Bos taurus N-acetyl-5-hydroxytryptamine
3.5.3.1 20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Mus musculus imidazole-3-lactate
3.5.3.1 20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Bos taurus imidazole-3-lactate