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Literature summary extracted from

  • Injeti, E.R.; Sandoval, R.J.; Williams, J.M.; Smolensky, A.V.; Ford, L.E.; Pearce, W.J.
    Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared to adult ovine carotid arteries (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H2289-H2298.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 Calmodulin
-
 Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 ML-7 specific inhibitor for MLCK Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.18 cytosol
-
 Ovis aries 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Ovis aries
2.7.11.18 Mg2+
-
 Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Ovis aries MLCK plays a critically important role in regulation of contraction in both smooth muscle and non-muscle cells, MLCK is both necessary and sufficient to initiate smooth muscle contraction ADP + myosin light chain phosphate
-
 ?
2.7.11.18 additional information Ovis aries postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain phosphorylation, relations between myosin light chain phosphorylation and contractile force, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Ovis aries O02827
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 artery maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared to adult ovine carotid arteries Ovis aries
-
2.7.11.18 carotid atherosclerotic plaque fetal and adult, quantification of the enzyme and its product Ovis aries
-
2.7.11.18 smooth muscle cell
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.18 additional information
-
 quantitative determination of phosphorylated myosin light chain Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Ovis aries ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain MLCK plays a critically important role in regulation of contraction in both smooth muscle and non-muscle cells, MLCK is both necessary and sufficient to initiate smooth muscle contraction Ovis aries ADP + myosin light chain phosphate
-
 ?
2.7.11.18 additional information postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain phosphorylation, relations between myosin light chain phosphorylation and contractile force, overview Ovis aries ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Ovis aries
2.7.11.18 myosin light chain kinase
-
 Ovis aries

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.18 37
-
 assay at Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.18 7.5
-
 assay at Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Ovis aries