EC Number | Cloned (Comment) | Organism |
---|---|---|
1.13.11.31 | gene alox15, expression analysis and genotyping of wild-type and iron-deficient mutant rats, gene alox15 doesnot respond to iron, transcription regulation via cytokines and growth factors, overview | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.13.11.31 | additional information | the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient Belgrade rats, the lipids are almoste absent in wild-type rats, overview | Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.31 | Fe2+ | dependent on | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.31 | arachidonate + O2 | Rattus norvegicus | the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient rats, the lipids are almoste absent in wild-type rats, overview | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.31 | Rattus norvegicus | Q02759 | wild-type Sprague-Dawley rats and iron-deficient Belgrade rats, three isozymes: platelet, leukocyte, and epidermis isozyme, Alox15 is a leukocyte-type isozyme | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.31 | blood platelet | - |
Rattus norvegicus | - |
1.13.11.31 | epidermis | - |
Rattus norvegicus | - |
1.13.11.31 | intestine | - |
Rattus norvegicus | - |
1.13.11.31 | leukocyte | Alox15 | Rattus norvegicus | - |
1.13.11.31 | liver | - |
Rattus norvegicus | - |
1.13.11.31 | additional information | the leukocyte-type isozyme is widely distributed in cell types, while the epidermis-type and the platelet-type isozymes are more limited | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.31 | arachidonate + O2 | - |
Rattus norvegicus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate | ? | |
1.13.11.31 | arachidonate + O2 | the enzyme is involved in production of biologically active lipid mediators, (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate, 13-HODE, and 13-HOTE, in the intestine of iron-deficient rats, the lipids are almoste absent in wild-type rats, overview | Rattus norvegicus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate | further metabolized to (5Z,8Z,10E,14Z)-(12S)-12-hydroxyeicosa-5,8,10,14-tetraenoate | ? | |
1.13.11.31 | additional information | intestinal leukocyte-type isozyme Alox15 shows poor or no 15-lipoxygenase activity, EC 1.13.11.33 | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.31 | 12-lipoxygenase | - |
Rattus norvegicus |
1.13.11.31 | Alox15 | - |
Rattus norvegicus |