Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Stefanovic-Racic, M.; Perdomo, G.; Mantell, B.S.; Sipula, I.J.; Brown, N.F.; ODoherty, R.M.
    A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels (2008), Am. J. Physiol. Endocrinol. Metab., 294, E969-E977.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.21 pharmacology the data represent proof in principle that a pharmacological agent that stimulates hepatic fatty acid oxidation, perhaps acting on carnitine palmitoyltransferase 1a, could provide a novel approach to treatment of nonalcoholic fatty liver disease Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.21 recombinant adenoviruses containing cDNAs encoding rat CPT1a and rat CPT2 are constructed Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrial outer membrane CPT1a Rattus norvegicus 5741
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-palmitoylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Rattus norvegicus P18886 male Sprague-Dawley rat
-
2.3.1.21 Rattus norvegicus P32198 male Sprague-Dawley rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 hepatocyte
-
 Rattus norvegicus
-
2.3.1.21 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 0.0006
-
 hepatocytes transduced with adenovirus encoding beta-galctosidase exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period Rattus norvegicus
2.3.1.21 0.0008
-
 hepatocytes transduced with adenovirus encoding CPT-2 exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period Rattus norvegicus
2.3.1.21 0.001
-
 hepatocytes transduced with adenovirus encoding beta-galctosidase exposed to exogenous palmitate, measurement of CPT-2 activity at the end of the incubation period Rattus norvegicus
2.3.1.21 0.0017
-
 hepatocytes transduced with adenovirus encoding CPT-1a exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period Rattus norvegicus
2.3.1.21 0.0019
-
 hepatocytes transduced with adenovirus encoding CPT-1a exposed to exogenous palmitate, measurement of CPT-2 activity at the end of the incubation period Rattus norvegicus
2.3.1.21 0.0021
-
 hepatic CPT-1 activity, rats fed standard diet, transduced with adenovirus encoding beta-galctosidase, incubation with palmitate Rattus norvegicus
2.3.1.21 0.0029
-
 hepatic CPT-1 activity, rats fed high-fat diet, transduced with adenovirus encoding beta-galctosidase, incubation with palmitate Rattus norvegicus
2.3.1.21 0.0029
-
 hepatic CPT-1 activity, rats fed standard diet, transduced with adenovirus encoding CPT-2, incubation with palmitate Rattus norvegicus
2.3.1.21 0.0033
-
 hepatic CPT-1 activity, rats fed high-fat diet, transduced with adenovirus encoding CPT-2, incubation with palmitate Rattus norvegicus
2.3.1.21 0.0041
-
 hepatic CPT-1 activity, rats fed standard diet, transduced with adenovirus encoding CPT-1a, incubation with palmitate Rattus norvegicus
2.3.1.21 0.0051
-
 hepatic CPT-1 activity, rats fed high-fat diet, transduced with adenovirus encoding CPT-1a, incubation with palmitate Rattus norvegicus
2.3.1.21 0.0063
-
 hepatocytes transduced with adenovirus encoding CPT-2 exposed to exogenous palmitate, measurement of CPT-2 activity at the end of the incubation period Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.21 carnitine O-palmitoyltransferase
-
 Rattus norvegicus
2.3.1.21 carnitine palmitoyltransferase 1A
-
 Rattus norvegicus
2.3.1.21 carnitine palmitoyltransferase 2
-
 Rattus norvegicus
2.3.1.21 CPT
-
 Rattus norvegicus
2.3.1.21 CPT1A
-
 Rattus norvegicus
2.3.1.21 CPT2
-
 Rattus norvegicus