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Literature summary extracted from
- Macrovascular changes in mice overexpressing human semicarbazide-sensitive amine oxidase in smooth muscle cells (2007), Am. J. Hypertens., 20, 743-750.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.4.3.21 | mice overexpressing human semicarbazide-sensitive amine oxidase in smooth muscle cells. No differences in elastin quantity or lung capacity could be observed between transgenic or nontransgenic littermates. Pulse pressure is higher in transgenic mice, and aorta shows elastin fibers parallel with the aorta wall (i. e., straight fibers instead of folded compared with control mice). No difference in the response to adrenaline or sodium chloride is observed between the transgenic and control mice. The control mice have a clear decrease in blood pressure with a longer duration as a response to injection of a nitric oxide donor, sodium nitroprusside, compared with transgenic mice where only a minor response is observed. The SSAO activity in serum of control mice is elevated in response to injection of the NO donor, but not in response to a ganglion blocker | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.21 | additional information | Homo sapiens | physiologic role for SSAO in elastin maturation | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.21 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.21 | benzylamine + H2O + O2 | - |
Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | additional information | physiologic role for SSAO in elastin maturation | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.21 | semicarbazide-sensitive amine oxidase | - |
Homo sapiens |
| 1.4.3.21 | SSAO | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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