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Literature summary extracted from
- Pokeweed antiviral protein depurinates the sarcin/ricin loop of the rRNA prior to binding of aminoacyl-tRNA to the ribosomal A-site (2006), RNA, 12, 1683-1692.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.2.2.22 | expression in Saccharomyces cerevisiae strain mak8-1 which is more resistant to the enzyme in vivo due to higher affinity for aminoacyl-tRNA | Phytolacca americana |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.2.22 | puromycin | prior incubation of ribosomes with puromycin inhibits both the binding and depurination by the enzyme | Phytolacca americana |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.2.22 | Phytolacca americana | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.2.22 | 25S rNA + H2O | - |
Phytolacca americana | ? | enzyme depurinates the sarcin/ricin loop when the A-site of the ribosomal peptidyl-transferase center is unoccupied | ? | |
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