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Literature summary extracted from

  • Zhao, Z.; Xiang, Z.; Haroutunian, V.; Buxbaum, J.D.; Stetka, B.; Pasinetti, G.M.
    Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimers disease (2007), Neurobiol. Aging, 28, 824-830.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.56 cytosol
-
 Homo sapiens 5829
-
3.4.24.56 membrane bound Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 insulin + H2O Homo sapiens degradation ?
-
 ?
3.4.24.56 additional information Homo sapiens membrane-bound, but not cytosolic, enzyme selectively decreases during hippocampal development from mild cognitive impairment to mild to severe Alzheimer's disease, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 brain post-mortal samples Homo sapiens
-
3.4.24.56 hippocampus
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.56 additional information
-
 cytosolic IDE and membrane-bound IDE activity, and clinical dementia scores, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 insulin + H2O degradation Homo sapiens ?
-
 ?
3.4.24.56 additional information membrane-bound, but not cytosolic, enzyme selectively decreases during hippocampal development from mild cognitive impairment to mild to severe Alzheimer's disease, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Homo sapiens
3.4.24.56 insulin degrading enzyme
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.56 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.56 7.4
-
 assay at Homo sapiens