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Literature summary extracted from

  • Scheiflinger, F.; Dockal, M.; Rosing, J.; Kerschbaumer, R.J.
    Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies (2008), J. Thromb. Haemost., 6, 315-322.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.22 factor IX-specific antibodies antibosies specific for human factor I, e.g. 198A1, 198B3, and 224F3, enhance the factor IXa activity mimicking the stimulatory effect of FVIIIa, and thus can replace FVIIIa as cofactor in the FX activation reaction, overview Homo sapiens
3.4.21.22 Factor VIIIa binds to the activated factor IX and enhances the activation of factor X by several orders of magnitude Homo sapiens
3.4.21.22 Phospholipid the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.22 extracellular
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.22 Ca2+ the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ Homo sapiens
3.4.21.22 Na+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.22 factor X + H2O Homo sapiens the enzyme acts in complex with factor VIIIa, FVIIIa deficiency causes the bleeding disorder hemaphilia A activated factor X + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.22 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.22 commercial preparation from plasma Homo sapiens
-
3.4.21.22 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.22 factor X + H2O the enzyme acts in complex with factor VIIIa, FVIIIa deficiency causes the bleeding disorder hemaphilia A Homo sapiens activated factor X + ?
-
 ?
3.4.21.22 factor X + H2O the reaction is performed by the intrinsic FX-activating complex consisting of FIXa and FVIIIa on a negatively charged phospholipid surface in presence of Ca2+ Homo sapiens activated factor X + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.22 activated coagulation factor IX
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.22 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.22 7.3 7.4 assay at Homo sapiens