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Literature summary extracted from

  • Kim, M.; Hersh, L.B.; Leissring, M.A.; Ingelsson, M.; Matsui, T.; Farris, W.; Lu, A.; Hyman, B.T.; Selkoe, D.J.; Bertram, L.; Tanzi, R.E.
    Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families (2007), J. Biol. Chem., 282, 7825-7832.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.56 genetic linkage and association of Alzheimer disease on chromosome 10q23-24 in the region harboring the IDE gene Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.56 additional information chromosome 10-linked Alzheimer disease families show decreased enzyme activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.56 Zn2+ a zinc metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 amyloid beta-peptide + H2O Homo sapiens degradation, amyloid beta-peptide is the key component of Alzheimer disease-associated senile plaques, genetic linkage and association of Alzheimer disease on chromosome 10q23-24 in the region harboring the IDE gene, chromosome 10-linked Alzheimer disease families show decreased enzyme activity, overview ?
-
 ?
3.4.24.56 insulin + H2O Homo sapiens degradation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Homo sapiens
-
 chromosome 10-linked Alzheimer disease families
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 brain
-
 Homo sapiens
-
3.4.24.56 lymphoblast
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.56 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 amyloid beta-peptide + H2O degradation Homo sapiens ?
-
 ?
3.4.24.56 amyloid beta-peptide + H2O degradation, amyloid beta-peptide is the key component of Alzheimer disease-associated senile plaques, genetic linkage and association of Alzheimer disease on chromosome 10q23-24 in the region harboring the IDE gene, chromosome 10-linked Alzheimer disease families show decreased enzyme activity, overview Homo sapiens ?
-
 ?
3.4.24.56 insulin + H2O degradation Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Homo sapiens
3.4.24.56 Insulin-degrading enzyme
-
 Homo sapiens