Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Segers, K.; Dahlbaeck, B.; Bock, P.E.; Tans, G.; Rosing, J.; Nicolaes, G.A.
    The role of thrombin exosites I and II in the activation of human coagulation factor V (2007), J. Biol. Chem., 282, 33915-33924.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.95 heparin at low concentrations, less than 5 units, binds heparin Daboia russelii
3.4.21.95 heparin at low concentrations, less than 5 units, binds heparin Macrovipera lebetina

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.95 heparin at high concentrations, more than 100 units Daboia russelii
3.4.21.95 heparin at high concentrations, more than 100 units Macrovipera lebetina

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.95 Daboia russelii
-
 Daboia ruscelli, RVV-V
-
3.4.21.95 Macrovipera lebetina
-
 Daboia lebetina turanica, LVV-V
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.95 human blood coagulation factor V + H2O snake venom proteases activates FV by a single cleavage at Arg1545, various mutated variants of blood coagulation factor V are used, snake venom protease require the C-terminal region of the B-domain for efficient activation of FV, this acidic region is importance for the recognition of the Arg1545 cleavage site by the venom FV activators Daboia russelii activated human blood coagulation factor V
-
 ?
3.4.21.95 human blood coagulation factor V + H2O snake venom proteases activates FV by a single cleavage at Arg1545, various mutated variants of blood coagulation factor V are used, snake venom protease require the C-terminal region of the B-domain for efficient activation of FV, this acidic region is importance for the recognition of the Arg1545 cleavage site by the venom FV activators Macrovipera lebetina activated human blood coagulation factor V
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.95 FV activating enzymes
-
 Daboia russelii
3.4.21.95 FV activating enzymes
-
 Macrovipera lebetina
3.4.21.95 Human blood coagulation Factor V activating enzymes
-
 Daboia russelii
3.4.21.95 Human blood coagulation Factor V activating enzymes
-
 Macrovipera lebetina
3.4.21.95 LVV-V
-
 Macrovipera lebetina
3.4.21.95 RVV-V
-
 Daboia russelii