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Literature summary extracted from

  • Cechowska-Pasko, M.; Palka, J.; Wojtukiewicz, M.Z.
    Enhanced prolidase activity and decreased collagen content in breast cancer tissue (2006), Int. J. Exp. Pathol., 87, 289-296.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.13.9 additional information prolidase activity is dependent on the interaction of collagen with the beta1-integrin receptor subunit Homo sapiens

Application

EC Number Application Comment Organism
3.4.13.9 drug development the enzyme is a target in breast cancer therapy Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.13.9 Mn2+ required for enzyme activation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.9 breast cancer cell breast cancer tissue shows high enzyme activity, reduced collagen content and decreased expression of beta1-integrins Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.9 Gly-Pro + H2O
-
 Homo sapiens Gly + Pro
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.13.9 prolidase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.13.9 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.13.9 7.8
-
 assay at Homo sapiens