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Literature summary extracted from

  • Lemberg, M.K.; Freeman, M.
    Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases (2007), Genome Res., 17, 1634-1646.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Drosophila melanogaster
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Mus musculus
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Homo sapiens
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Saccharomyces cerevisiae
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Plasmodium falciparum
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Toxoplasma gondii
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Escherichia coli
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Providencia stuartii
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Pseudomonas aeruginosa
3.4.21.105 DNA and amino acid sequence analysis, phylogenetic analysis, overview Bacillus subtilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Drosophila melanogaster 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Mus musculus 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Homo sapiens 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Saccharomyces cerevisiae 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Plasmodium falciparum 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Toxoplasma gondii 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Escherichia coli 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Providencia stuartii 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Pseudomonas aeruginosa 16020
-
3.4.21.105 membrane the enzyme is an intramembrane serine protease, intramembrane rhomboid topology, modeling, overview Bacillus subtilis 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.105 additional information Drosophila melanogaster the enzyme is involved in regulation of growth factor signaling, and mitochondrial fusion ?
-
 ?
3.4.21.105 additional information Mus musculus the enzyme is involved in regulation of growth factor signaling, and mitochondrial fusion ?
-
 ?
3.4.21.105 additional information Homo sapiens the enzyme is involved in regulation of growth factor signaling, and mitochondrial fusion ?
-
 ?
3.4.21.105 additional information Saccharomyces cerevisiae the enzyme is involved in regulation of growth factor signaling, and mitochondrial fusion ?
-
 ?
3.4.21.105 additional information Plasmodium falciparum the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion ?
-
 ?
3.4.21.105 additional information Toxoplasma gondii the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion ?
-
 ?
3.4.21.105 additional information Escherichia coli the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion ?
-
 ?
3.4.21.105 additional information Providencia stuartii the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion ?
-
 ?
3.4.21.105 additional information Pseudomonas aeruginosa the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion ?
-
 ?
3.4.21.105 additional information Bacillus subtilis the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.105 Bacillus subtilis P54493 gene yqgP or gluP
-
3.4.21.105 Drosophila melanogaster
-
-
-
3.4.21.105 Escherichia coli P09391 gene glpG
-
3.4.21.105 Homo sapiens
-
-
-
3.4.21.105 Mus musculus
-
-
-
3.4.21.105 Plasmodium falciparum
-
-
-
3.4.21.105 Providencia stuartii P46116 gene aarA
-
3.4.21.105 Pseudomonas aeruginosa Q9HZC2 gene PA3086
-
3.4.21.105 Saccharomyces cerevisiae
-
-
-
3.4.21.105 Toxoplasma gondii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, and mitochondrial fusion Drosophila melanogaster ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, and mitochondrial fusion Mus musculus ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, and mitochondrial fusion Homo sapiens ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, and mitochondrial fusion Saccharomyces cerevisiae ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion Plasmodium falciparum ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion Toxoplasma gondii ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion Escherichia coli ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion Providencia stuartii ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion Pseudomonas aeruginosa ?
-
 ?
3.4.21.105 additional information the enzyme is involved in regulation of growth factor signaling, mitochondrial fusion, and parasite invasion Bacillus subtilis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Drosophila melanogaster
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Mus musculus
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Homo sapiens
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Saccharomyces cerevisiae
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Plasmodium falciparum
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Toxoplasma gondii
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Escherichia coli
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Providencia stuartii
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Pseudomonas aeruginosa
3.4.21.105 More determination and classification of intramembrane rhomboid topology, modeling, overview Bacillus subtilis

Synonyms

EC Number Synonyms Comment Organism
3.4.21.105 AarA
-
 Providencia stuartii
3.4.21.105 GlpG
-
 Escherichia coli
3.4.21.105 PARL
-
 Mus musculus
3.4.21.105 Pcp1/Rbd1
-
 Saccharomyces cerevisiae
3.4.21.105 RHBDL2
-
 Homo sapiens
3.4.21.105 rhomboid intramembrane protease
-
 Drosophila melanogaster
3.4.21.105 rhomboid intramembrane protease
-
 Mus musculus
3.4.21.105 rhomboid intramembrane protease
-
 Homo sapiens
3.4.21.105 rhomboid intramembrane protease
-
 Saccharomyces cerevisiae
3.4.21.105 rhomboid intramembrane protease
-
 Plasmodium falciparum
3.4.21.105 rhomboid intramembrane protease
-
 Toxoplasma gondii
3.4.21.105 rhomboid intramembrane protease
-
 Escherichia coli
3.4.21.105 rhomboid intramembrane protease
-
 Providencia stuartii
3.4.21.105 rhomboid intramembrane protease
-
 Pseudomonas aeruginosa
3.4.21.105 rhomboid intramembrane protease
-
 Bacillus subtilis
3.4.21.105 rhomboid-1
-
 Drosophila melanogaster
3.4.21.105 ROM1
-
 Plasmodium falciparum
3.4.21.105 ROM4
-
 Plasmodium falciparum
3.4.21.105 ROM5
-
 Toxoplasma gondii
3.4.21.105 Yqgp
-
 Bacillus subtilis