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Literature summary extracted from
- Characterisation of endothelin converting enzyme-1 shedding from endothelial cells (2007), FEBS Lett., 581, 4501-4506.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.71 | phosphoramidon | - |
Homo sapiens |  |
| 3.4.24.71 | thiorphan | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.71 | cell surface | ECE-1 shedding from the surface of endothelial cells | Homo sapiens | 9986 | - |
| 3.4.24.71 | extracellular | - |
Homo sapiens | - |
- |
| 3.4.24.71 | membrane | - |
Homo sapiens | 16020 | - |
| 3.4.24.71 | soluble | - |
Homo sapiens | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.71 | Ca2+ | metalloprotease | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.71 | big endothelin-1 + H2O | Homo sapiens | activation | endothelin-1 + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.71 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.71 | umbilical vein endothelial cell | ECE-1 is secreted to the medium, ECE-1 shedding from the surface of endothelial cells | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.71 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.71 | (7-methoxy-coumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl) + H2O | fluorogenic substrate | Homo sapiens | ? | - |
? | |
| 3.4.24.71 | big endothelin-1 + H2O | activation | Homo sapiens | endothelin-1 + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.71 | ECE-1 | - |
Homo sapiens |
| 3.4.24.71 | endothelin-converting enzyme-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.71 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.71 | 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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