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Literature summary extracted from
- Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis (2007), Development, 134, 3461-3471.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.21.109 | additional information | enzyme and hepatocyte growth factor activator inhibitor-1, Hai1, deficient phenotype, hai1 mutant defects are rescued by inactivation of matriptase1a, overview | Danio rerio |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.109 | hepatocyte growth factor activator inhibitor-1 | Hai1a, i.e. Spint1Ia, enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, inhibitor mutant zebrafish show disrupted epidermal integrity, enhanced upon combined loss of hai1a and the paralogue hai1b, overview | Danio rerio |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.109 | additional information | Danio rerio | enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, Hai1 and matriptase1a are involved in regualtion of skin homeostasis and remodeling, overview | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.109 | Danio rerio | - |
zebrafish | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.109 | epidermis | enzyme expression in developing basal layer of the epidermis, enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, overview | Danio rerio | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.109 | additional information | enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, Hai1 and matriptase1a are involved in regualtion of skin homeostasis and remodeling, overview | Danio rerio | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.109 | matriptase1 | - |
Danio rerio |
| 3.4.21.109 | matriptase1a | - |
Danio rerio |
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