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Literature summary extracted from
- Structure, function and biological relevance of prolyl oligopeptidase (2008), Curr. Protein Pept. Sci., 9, 96-107.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | pharmacology | microbial PEPs are studied as potential therapeutics for celiac sprue, an inflammatory disease of the small intestine triggered by proline-rich gluten | Pyrococcus furiosus |
| 3.4.21.26 | pharmacology | microbial PEPs are studied as potential therapeutics for celiac sprue, an inflammatory disease of the small intestine triggered by proline-rich gluten | Myxococcus xanthus |
| 3.4.21.26 | pharmacology | microbial PEPs are studied as potential therapeutics for celiac sprue, an inflammatory disease of the small intestine triggered by proline-rich gluten | Elizabethkingia meningoseptica |
| 3.4.21.26 | pharmacology | microbial PEPs are studied as potential therapeutics for celiac sprue, an inflammatory disease of the small intestine triggered by proline-rich gluten | Novosphingobium capsulatum |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | ((8'Z)-pentadecenyl)-salicylic acid | a noncompetitive inhibitor isolated from Gingko biloba leaves | Homo sapiens |  |
| 3.4.21.26 | 33mer of gluten-derived peptide | - |
Sus scrofa | |
| 3.4.21.26 | 6-((10'Z)-heptadecenyl)salicylic acid | a noncompetitive inhibitor isolated from Gingko biloba leaves | Homo sapiens | |
| 3.4.21.26 | caproyl-L-Pro-((2S)-hydroxyacetyl)pyrrolidine | - |
Homo sapiens | |
| 3.4.21.26 | carbamazepine | mechanism, reverses the effect of drugs | Dictyostelium discoideum | |
| 3.4.21.26 | JTP-4819 | a selective POP inhibitor, physiological effects, overview | Homo sapiens | |
| 3.4.21.26 | JTP-4819 | a selective POP inhibitor, physiological effects, overview | Mus musculus | |
| 3.4.21.26 | JTP-4819 | a selective POP inhibitor, physiological effects, overview | Platyrrhini | |
| 3.4.21.26 | JTP-4819 | a selective POP inhibitor, physiological effects, overview | Rattus norvegicus | |
| 3.4.21.26 | JTP-4819 | a selective POP inhibitor, physiological effects, overview | Sus scrofa | |
| 3.4.21.26 | lithium | mechanism, reverses the effect of drugs | Dictyostelium discoideum | |
| 3.4.21.26 | ONO-1603 | - |
Homo sapiens | |
| 3.4.21.26 | ONO-1603 | - |
Mus musculus | |
| 3.4.21.26 | ONO-1603 | - |
Platyrrhini | |
| 3.4.21.26 | ONO-1603 | - |
Rattus norvegicus | |
| 3.4.21.26 | ONO-1603 | - |
Sus scrofa | |
| 3.4.21.26 | propeptin | a netural inhibitor of POP isolated from Microbispora sp. strain SNA-115 | Elizabethkingia meningoseptica | |
| 3.4.21.26 | S 17092 | physiological effects, overview | Homo sapiens | |
| 3.4.21.26 | S 17092 | physiological effects, overview | Mus musculus | |
| 3.4.21.26 | S 17092 | physiological effects, overview | Platyrrhini | |
| 3.4.21.26 | S 17092 | physiological effects, overview | Rattus norvegicus | |
| 3.4.21.26 | S 17092 | physiological effects, overview | Sus scrofa | |
| 3.4.21.26 | Tyr-Pro-Ile-Pro-Phe | inhibitory peptide isolated from grapes of Cabernet Sauvignon | Elizabethkingia meningoseptica | |
| 3.4.21.26 | Val-Glu-Ile-Pro-Glu | inhibitory peptide isolated from grapes of Cabernet Sauvignon | Elizabethkingia meningoseptica | |
| 3.4.21.26 | Valproic acid | mechanism, reverses the effect of drugs | Dictyostelium discoideum | |
| 3.4.21.26 | Z-Pro-prolinal | - |
Homo sapiens | |
| 3.4.21.26 | Z-Pro-prolinal | - |
Mus musculus | |
| 3.4.21.26 | Z-Pro-prolinal | physiological effects, overview | Rattus norvegicus | |
| 3.4.21.26 | Z-Pro-prolinal | - |
Sus scrofa | |
| 3.4.21.26 | Z-thioprolyl-thioprolinal-dimethylacetal | physiological effects, overview | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Mus musculus | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Homo sapiens | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Rattus norvegicus | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Sus scrofa | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Pyrococcus furiosus | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Dictyostelium discoideum | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Myxococcus xanthus | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Platyrrhini | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Elizabethkingia meningoseptica | |
| 3.4.21.26 | additional information | - |
additional information | kinetics mechanism | Novosphingobium capsulatum |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.26 | cytoskeleton | the enzyme is co-localized with tubulin | Homo sapiens | 5856 | - |
| 3.4.21.26 | cytoskeleton | the enzyme is co-localized with tubulin | Rattus norvegicus | 5856 | - |
| 3.4.21.26 | cytosol | - |
Homo sapiens | 5829 | - |
| 3.4.21.26 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 3.4.21.26 | extracellular | - |
Homo sapiens | - |
- |
| 3.4.21.26 | extracellular | - |
Rattus norvegicus | - |
- |
| 3.4.21.26 | membrane | - |
Homo sapiens | 16020 | - |
| 3.4.21.26 | membrane | - |
Rattus norvegicus | 16020 | - |
| 3.4.21.26 | perinuclear space | - |
Homo sapiens | - |
- |
| 3.4.21.26 | perinuclear space | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | arginine-vasopressin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | gluten + H2O | Pyrococcus furiosus | - |
? | - |
? | |
| 3.4.21.26 | gluten + H2O | Myxococcus xanthus | - |
? | - |
? | |
| 3.4.21.26 | gluten + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | gluten + H2O | Novosphingobium capsulatum | - |
? | - |
? | |
| 3.4.21.26 | gluten peptide + H2O | Pyrococcus furiosus | - |
? | - |
? | |
| 3.4.21.26 | gluten peptide + H2O | Myxococcus xanthus | - |
? | - |
? | |
| 3.4.21.26 | gluten peptide + H2O | Elizabethkingia meningoseptica | - |
? | - |
? | |
| 3.4.21.26 | gluten peptide + H2O | Novosphingobium capsulatum | - |
? | - |
? | |
| 3.4.21.26 | additional information | Pyrococcus furiosus | cellular functions, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Myxococcus xanthus | cellular functions, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Elizabethkingia meningoseptica | cellular functions, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Novosphingobium capsulatum | cellular functions, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Rattus norvegicus | cellular functions, overview, POP may regulate phosphoinositide signaling, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Sus scrofa | cellular functions, overview, POP may regulate phosphoinositide signaling, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Dictyostelium discoideum | cellular functions, overview, POP may regulate phosphoinositide signaling, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Platyrrhini | cellular functions, overview, POP may regulate phosphoinositide signaling, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Mus musculus | cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Homo sapiens | cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in neuronal degeneration and Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Dictyostelium discoideum | - |
- |
- |
| 3.4.21.26 | Elizabethkingia meningoseptica | - |
- |
- |
| 3.4.21.26 | Homo sapiens | - |
- |
- |
| 3.4.21.26 | Mus musculus | - |
- |
- |
| 3.4.21.26 | Myxococcus xanthus | - |
- |
- |
| 3.4.21.26 | Novosphingobium capsulatum | - |
- |
- |
| 3.4.21.26 | Platyrrhini | - |
- |
- |
| 3.4.21.26 | Pyrococcus furiosus | - |
- |
- |
| 3.4.21.26 | Rattus norvegicus | - |
- |
- |
| 3.4.21.26 | Sus scrofa | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | the catalytic triad Ser554, Asp641, His680 is located at the C-terminus in a large cavity at the interface of the two domains, the serine residue is located on what is called a nucleophile elbow, at the tip of a very sharp turn, it is surrounded by several small residues that provide relatively little steric hindrance, catalytic mechanism, structure-function relationship, overview | Homo sapiens | |
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | the catalytic triad Ser554, Asp641, His680 is located at the C-terminus in a large cavity at the interface of the two domains, the serine residue is located on what is called a nucleophile elbow, at the tip of a very sharp turn, it is surrounded by several small residues that provide relatively little steric hindrance, catalytic mechanism, structure-function relationship, overview | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | brain | - |
Mus musculus | - |
| 3.4.21.26 | brain | - |
Homo sapiens | - |
| 3.4.21.26 | brain | - |
Sus scrofa | - |
| 3.4.21.26 | brain cortex | - |
Rattus norvegicus | - |
| 3.4.21.26 | cerebellum | - |
Rattus norvegicus | - |
| 3.4.21.26 | HEK-293 cell | - |
Homo sapiens | - |
| 3.4.21.26 | hippocampus | - |
Mus musculus | - |
| 3.4.21.26 | hippocampus | - |
Homo sapiens | - |
| 3.4.21.26 | hippocampus | - |
Rattus norvegicus | - |
| 3.4.21.26 | additional information | no enzyme activity in intestinal brush-border membranes and pancreas | Homo sapiens | - |
| 3.4.21.26 | additional information | no enzyme activity in intestinal brush-border membranes and pancreas | Rattus norvegicus | - |
| 3.4.21.26 | neuron | - |
Mus musculus | - |
| 3.4.21.26 | neuron | - |
Homo sapiens | - |
| 3.4.21.26 | semen | - |
Homo sapiens | - |
| 3.4.21.26 | seminal fluid | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | arginine-vasopressin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | gluten + H2O | - |
Pyrococcus furiosus | ? | - |
? | |
| 3.4.21.26 | gluten + H2O | - |
Myxococcus xanthus | ? | - |
? | |
| 3.4.21.26 | gluten + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | gluten + H2O | - |
Novosphingobium capsulatum | ? | - |
? | |
| 3.4.21.26 | gluten peptide + H2O | - |
Pyrococcus furiosus | ? | - |
? | |
| 3.4.21.26 | gluten peptide + H2O | - |
Myxococcus xanthus | ? | - |
? | |
| 3.4.21.26 | gluten peptide + H2O | - |
Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | gluten peptide + H2O | - |
Novosphingobium capsulatum | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview | Pyrococcus furiosus | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview | Myxococcus xanthus | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview | Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview | Novosphingobium capsulatum | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview, POP may regulate phosphoinositide signaling, overview | Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview, POP may regulate phosphoinositide signaling, overview | Sus scrofa | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview, POP may regulate phosphoinositide signaling, overview | Dictyostelium discoideum | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview, POP may regulate phosphoinositide signaling, overview | Platyrrhini | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview | Mus musculus | ? | - |
? | |
| 3.4.21.26 | additional information | cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in neuronal degeneration and Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview | Homo sapiens | ? | - |
? | |
| 3.4.21.26 | additional information | no activity with gluten in celiac sprue patients, substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Homo sapiens | ? | - |
? | |
| 3.4.21.26 | additional information | no activity with gluten in celiac sprue patients, substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Sus scrofa | ? | - |
? | |
| 3.4.21.26 | additional information | no activity with gluten in celiac sprue rats, substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Mus musculus | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Pyrococcus furiosus | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Dictyostelium discoideum | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Myxococcus xanthus | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Platyrrhini | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity with exclusion of peptides with more than 30 amino acids, overview | Novosphingobium capsulatum | ? | - |
? | |
| 3.4.21.26 | N-succinyl-Gly-Pro-OH + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | POP | - |
Mus musculus |
| 3.4.21.26 | POP | - |
Homo sapiens |
| 3.4.21.26 | POP | - |
Rattus norvegicus |
| 3.4.21.26 | POP | - |
Sus scrofa |
| 3.4.21.26 | POP | - |
Pyrococcus furiosus |
| 3.4.21.26 | POP | - |
Dictyostelium discoideum |
| 3.4.21.26 | POP | - |
Myxococcus xanthus |
| 3.4.21.26 | POP | - |
Platyrrhini |
| 3.4.21.26 | POP | - |
Elizabethkingia meningoseptica |
| 3.4.21.26 | POP | - |
Novosphingobium capsulatum |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | 0.0008 | - |
6-((10'Z)-heptadecenyl)salicylic acid | - |
Homo sapiens | |
| 3.4.21.26 | 0.00087 | - |
((8'Z)-pentadecenyl)-salicylic acid | - |
Homo sapiens | |
| 3.4.21.26 | 0.278 | - |
N-succinyl-Gly-Pro-OH | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | 0.00000083 | - |
- |
Homo sapiens | caproyl-L-Pro-((2S)-hydroxyacetyl)pyrrolidine | |
| 3.4.21.26 | 0.017 | - |
- |
Elizabethkingia meningoseptica | Val-Glu-Ile-Pro-Glu | |
| 3.4.21.26 | 0.0878 | - |
- |
Elizabethkingia meningoseptica | Tyr-Pro-Ile-Pro-Phe | |
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